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Behavior in Huntington's disease: dissociating cognition-based and mood-based changes.

Jennifer C Thompson1, Julie S Snowden, David Craufurd

  • 1Cerebral Function Unit, Greater Manchester Neuroscience Center, Salford, United Kingdom. jennifer.thompson@man.ac.uk

The Journal of Neuropsychiatry and Clinical Neurosciences
|March 9, 2002
PubMed
Summary

Apathy is linked to cognitive and motor decline in Huntington's disease (HD). Irritability and depression showed no correlation, suggesting some behavioral changes are intrinsic to HD progression.

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Area of Science:

  • Neuroscience
  • Neurology
  • Behavioral Science

Background:

  • Huntington's disease (HD) is a progressive neurodegenerative disorder.
  • Behavioral changes are common in HD, but their relationship to disease progression is not fully understood.

Purpose of the Study:

  • To investigate the association between specific behavioral dimensions and the severity of cognitive and motor impairments in Huntington's disease.

Main Methods:

  • The Problem Behaviors Assessment for Huntington's Disease (PBA-HD) was used to measure apathy, depression, and irritability.
  • These behavioral measures were correlated with established cognitive and motor assessments of HD severity.

Main Results:

  • The Apathy subscale of the PBA-HD demonstrated a significant correlation with both cognitive deficits and motor impairments.

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  • In contrast, the Irritability and Depression subscales did not show a significant relationship with these disease severity indices.

    • Conclusions:

    • Apathy appears to be an intrinsic behavioral symptom directly related to the progression of Huntington's disease.
    • Other behavioral changes, such as irritability and depression, may be more variable and not directly linked to the core pathological progression of HD.