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Diffuse pulmonary neuroendocrine cell hyperplasia: radiologic and clinical features
Jin Seong Lee1, Kevin K Brown, Carlyne Cool
1Department of Radiology, Health Sciences Center, University of Colorado School of Medicine, Denver, CO, USA. jslee@www.amc.seoul.kr
Journal of Computer Assisted Tomography
|March 9, 2002
Summary
Pulmonary neuroendocrine cell hyperplasia shows mosaic patterns on CT scans, linked to airway obstruction. This condition involves air trapping and airway wall thickening, with occasional nodules.
Area of Science:
- Pulmonary Medicine
- Radiology
- Pathology
Background:
- Pulmonary neuroendocrine cell hyperplasia (PNEC) is a rare condition.
- Understanding its radiologic features is crucial for diagnosis.
Observation:
- High-resolution CT (HRCT) was used to evaluate five patients diagnosed with PNEC.
- Radiologists assessed airway wall thickening, mosaic pattern, air trapping, ground-glass opacity, nodular opacity, and centrilobular opacity.
Findings:
- Mosaic pattern was the predominant HRCT finding in all patients.
- The extent of mosaic pattern correlated with reduced forced expiratory volume in 1 second/forced vital capacity ratio (r = 0.8508, p = 0.0317).
- Nodular lesions, airway wall thickening, ground-glass opacity, and centrilobular opacity were also observed in some patients.
Implications:
- PNEC is characterized by mosaic perfusion on HRCT, resulting from air trapping and airway wall thickening.
- The degree of mosaic perfusion on imaging correlates with physiological evidence of airway obstruction.
- HRCT findings can aid in the diagnosis and assessment of PNEC severity.