Contrast-enhanced MRI of the liver with mangafodipir trisodium: imaging technique and results

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Dushyant V Sahani1, Martin E O'Malley, Sandeep Bhat

  • 1Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Journal of Computer Assisted Tomography
|March 9, 2002
PubMed

Insights

Mangafodipir trisodium (Mn-DPDP) enhances liver MRI visualization of focal liver lesions. This hepatobiliary contrast agent helps differentiate hepatocellular tumors from non-hepatocellular tumors based on uptake patterns.

Area of Science:

  • Radiology
  • Medical Imaging
  • Hepatobiliary Imaging

Background:

  • Magnetic resonance (MR) contrast agents are crucial for liver lesion detection and characterization.
  • Mangafodipir trisodium (Mn-DPDP) is a liver-specific, hepatobiliary MRI contrast agent.
  • It is taken up by hepatocytes and excreted via the biliary system, enhancing T1-weighted signal in normal liver parenchyma.

Observation:

  • Non-hepatocellular tumors typically appear hypointense compared to enhanced liver parenchyma on T1-weighted images.
  • Tumors of hepatocellular origin, including focal nodular hyperplasia (FNH), adenoma, and well-differentiated hepatocellular carcinomas (HCC), can accumulate Mn-DPDP.

Findings:

  • Mn-DPDP uptake provides valuable characterization information for liver tumors.
  • This allows for discrimination between hepatocellular and non-hepatocellular origins.
  • The enhanced imaging aids in lesion conspicuity compared to unenhanced scans.

Implications:

  • Mangafodipir-enhanced MR imaging improves the diagnostic accuracy of liver tumor characterization.
  • It aids in differentiating benign from malignant liver lesions.
  • This technique offers a valuable tool for radiologists in evaluating focal liver lesions.

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