Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone growth is impaired by uranium intoxication.

A M Ubios1, M J Piloni, M Marzorati

  • 1Department of Pathology, Faculty of Dentistry, University of Buenos Aires.

Acta Odontologica Latinoamericana : AOL
|January 1, 1994
PubMed
Summary

Uranium exposure, through injection or skin absorption, stunts bone growth in rats. This study shows uranium intoxication significantly reduces tibia and mandible length, impacting overall bone development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiopulmonary and skeletal muscle strategies underlying exhaustive exercise in adults with glycogen storage disease type III.

Physiological reports·2026
Same author

Acute hypoxia alters visuospatial attention orienting: an electrical neuroimaging study.

Scientific reports·2023
Same author

<i>Lacticaseibacillus rhamnosus</i> GG and <i>Saccharomyces cerevisiae boulardii</i> supplementation exert protective effects on human gut microbiome following antibiotic administration <i>in vitro</i>.

Beneficial microbes·2021
Same author

Effects of acute and sub-acute hypobaric hypoxia on oxidative stress: a field study in the Alps.

European journal of applied physiology·2020
Same author

<i>Lactobacillus rhamnosus</i> GG and <i>Saccharomyces cerevisiae boulardii</i> exert synergistic antipathogenic activity <i>in vitro</i> against enterotoxigenic <i>Escherichia coli</i>.

Beneficial microbes·2020
Same author

Fine Structural Localization of Thiamine Pyrophosphatase in Normal Human Gingiva.

Journal of periodontology·2018

Area of Science:

  • Toxicology
  • Biometry
  • Bone Biology

Background:

  • Uranium intoxication inhibits bone formation, modeling, and remodeling.
  • Bone growth is crucial for skeletal development and integrity.

Purpose of the Study:

  • To investigate the biometric effects of uranium intoxication on bone growth.
  • To assess uranium's impact on rat tibia and mandible development.

Main Methods:

  • Wistar rats were exposed to uranyl nitrate via intraperitoneal injection (IPI).
  • Rats also underwent percutaneous absorption (PA) of U3O8 for 30 days.
  • Tibia and mandible lengths were measured biometrically.

Main Results:

  • Uranium intoxication significantly reduced tibia and mandible length in both IPI and PA groups compared to controls.

Related Experiment Videos

  • Alterations in mandibular shape were observed in intoxicated rats.
  • Bone growth impairment was evident in uranium-exposed animals.

    • Conclusions:

    • Uranium intoxication demonstrably impairs bone growth.
    • Both acute and chronic uranium exposure negatively affect skeletal development.
    • Biometric analysis confirms uranium's detrimental effects on bone dimensions.