Search research articles

Search research articles

Related Experiment Videos

Protein profile in leprosy.

N Kurade¹, P K Dhamanaskar, V H Jadhav

¹Dr. Bandorawalla Leprosy Hospital, Pune.

Indian Journal of Medical Sciences

|March 12, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Disseminated histoplamosis.

Indian journal of medical microbiology·2006

Same author

Tissue concentration, systemic distribution and toxicity of clofazimine--an autopsy study.

Indian journal of pathology & microbiology·2005

Same author

Epithelioid angiomyolipoma of the kidney mimicking renal sarcoma.

Histopathology·2005

Same author

A study of mast cells in granulomatous lesions of skin, with special emphasis on leprosy.

Indian journal of leprosy·2004

Same author

Pathology of Toxoplasma myocarditis in acquired immunodeficiency syndrome.

Indian journal of pathology & microbiology·2004

Same author

Dedifferentiated chordoma--a case report.

Indian journal of pathology & microbiology·2003

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Serum protein and fibrinogen levels change across leprosy types, with higher globulin and fibrinogen seen in more severe forms. These protein changes may help predict leprosy reaction outcomes.

Area of Science:

Immunology
Clinical Biochemistry
Dermatology

Background:

Leprosy exhibits a wide immunological spectrum, from Tuberculoid (TT) to Lepromatous (LL) forms.
Leprosy reactions, particularly Type II, are associated with significant inflammatory responses.
Changes in serum protein profiles are often indicative of systemic inflammation and disease activity.

Purpose of the Study:

To investigate alterations in serum proteins and plasma fibrinogen across the leprosy immunological spectrum.
To evaluate changes in these parameters during Type II leprosy reactions (erythema nodosum leprosum - ENL).
To explore the prognostic value of these biochemical markers in leprosy and its reactions.

Main Methods:

Quantification of total proteins, albumin, globulin, and fibrinogen in serum and plasma samples.

Related Experiment Videos

Analysis of 103 leprosy patients across various clinical forms (TT to LL).

Assessment of 52 patients with reactional leprosy, including ENL, before and after treatment.

Main Results:

A significant increase in total proteins, globulin, and fibrinogen, alongside a decrease in albumin, was observed along the TT to LL spectrum.
Type II reactional leprosy showed a significant rise in globulin and fibrinogen levels.
These protein fractions significantly decreased in ENL patients post-reaction subsidence and steroid treatment.

Conclusions:

Serum protein and plasma fibrinogen levels vary significantly across the leprosy immunological spectrum and during reactions.
The observed changes in protein fractions, particularly globulin and fibrinogen, correlate with disease severity and inflammatory activity.
These biochemical markers hold potential prognostic implications for managing leprosy and its inflammatory complications like ENL.