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Related Experiment Videos

Intermittent claudication: its natural course.

A M Imparato, G E Kim, T Davidson

    Surgery
    |December 1, 1975
    PubMed
    Summary
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    Intermittent claudication is generally benign, with a low amputation rate. Below-knee arterial disease severity significantly impacts prognosis, indicating poor collateral circulation is a key factor.

    Area of Science:

    • Vascular Surgery
    • Interventional Cardiology
    • Peripheral Artery Disease

    Background:

    • Intermittent claudication is a common symptom of peripheral artery disease.
    • Non-surgical management is often considered for patients with less severe symptoms.
    • Long-term outcomes for non-surgical candidates require further investigation.

    Purpose of the Study:

    • To evaluate the natural history of intermittent claudication in patients not primarily selected for surgery.
    • To identify prognostic factors influencing disease progression and outcomes.
    • To assess the rate of amputation and need for revascularization.

    Main Methods:

    • Retrospective analysis of 104 patients with intermittent claudication undergoing angiographic studies.
    • Follow-up period ranging from 6 months to 8 years (mean 2.5 years).

    Related Experiment Videos

  • Classification of claudication severity and assessment of below-knee arterial runoff.

    • Main Results:

    • 82% of patients remained stable or improved; 22% worsened.
    • Amputation occurred in 5.8% of patients over a mean 2.5-year follow-up.
    • Below-knee runoff severity was a significant predictor of amputation risk.

    Conclusions:

    • Intermittent claudication has a relatively benign natural history for most non-surgical candidates.
    • The severity of below-knee arterial disease and collateral circulation significantly influences prognosis.
    • Angiography is crucial for assessing runoff and predicting outcomes in these patients.