Related Experiment Video
Updated: Jul 11, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Dynamics of LDL oxidation in ischemic stroke patients
D Ryglewicz1, M Rodo, M Roszczynko
11st Neurological Department, Institute of Psychiatry and Neurology, Warsaw, Poland. ryglew@ipin.edu.pl
Objective:
Oxidative modification of human low density lipoprotein (LDL) plays an important role in the development of atherosclerosis. The aim of this study was to evaluate the oxidative modification of LDL in the group of patients with ischemic stroke.
Material And Methods:
In the group of 43 patients 3 months after ischemic stroke and in the age and sex-matched control group, the kinetics of LDL oxidation and level of vitamin E were estimated. The susceptibility of LDL to oxidation was evaluated in isolated LDL exposed to in vitro oxidation. In 26 patients, after diet change, clinical and laboratory investigations were repeated 9 months later.
Results:
In the patient group, susceptibility of LDL to oxidation was enhanced, lag phase was significantly shorter in comparison with the control group. After a change in diet, significant elongation of the lag phase was observed.
Conclusion:
Diet change improves LDL resistance to oxidation and may influence prognosis in stroke patients.
Related Concept Videos
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Coronary Artery Disease II: Pathophysiology
Atherosclerosis I: Introduction
Atherosclerosis III: Management
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology

