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Published on: January 12, 2024
Human lymphocyte antigen DR7 protects against proliferative retinopathy with type II diabetes mellitus
Hugo Quiroz-Mercado1, Ana Suárez-Licona, Jans Fromow-Guerra
1Servicio de Retina, Hospital Luis Sánchez Bulnes, Asociación para Evitar la Ceguera en México (AECM), Calle Vicente García Torres #46, Col. San Lucas Coyoacán, 04030 Mexico City, D.F., Mexico. retinamex@yahoo.com
Background:
This study was undertaken in order to analyze the genetic incidence of human lymphocyte antigen diabetic retinopathy (HLA-DR) and its influence in proliferative diabetic retinopathy (PDR).
Methods:
We designed a case-control study in which 127 mestizo Mexican patients with DM II and diabetic retinopathy were studied. DNA was extracted and HLA-DR regions were amplified using PCR. Alleles were determined by DNA hybridization. Diagnosis was assessed clinically and by fluorescein angiography. Incidence of HLA-DR alleles in patients was compared with an ethnically matched control group of healthy subjects (n = 98). Statistical significance was established with non-parametric tests.
Results:
Patients with diabetic retinopathy showed less frequency of HLA-D11 compared with the control group (p = 0.043). NPDR patients with 10 or more years of DM II showed an increase of HLA-DR7 (p = 0.01).
Conclusions:
Our results suggest that the presence of HLA-DR7 protects against the development of proliferative disease in the diabetic Mexican population.
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