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Related Experiment Videos

Cytokine pattern in postmenopause.

Michele Cioffi1, Katherine Esposito, Maria Teresa Vietri

  • 1Patologia clinica, Dipartimento di Patologia Generale, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Via S. Andrea delle Dame, 2-80138, Naples, Italy. michele.cioffi@unina2.it

Maturitas
|March 12, 2002
PubMed
Summary
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Postmenopausal women exhibit altered serum cytokine profiles, with higher IL-6 and IL-18 levels compared to fertile women. This shift suggests a potential prevalence of Th2 lymphocytes during menopause.

Area of Science:

  • Endocrinology
  • Immunology
  • Reproductive Health

Background:

  • Menopause is associated with significant hormonal changes.
  • Cytokine profiles can be indicative of immune system status.
  • Hormonal shifts during menopause may influence immune responses.

Purpose of the Study:

  • To investigate serum cytokine patterns in postmenopausal women.
  • To explore the relationship between hormonal status and cytokine production.
  • To compare cytokine profiles between fertile and postmenopausal women.

Main Methods:

  • Recruitment of 82 healthy women (34 fertile, 48 postmenopausal).
  • Exclusion of smokers and hormone replacement therapy users.
  • Measurement of serum sex hormones, GH, IGF-1, and various cytokines (IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-18, IFN-gamma, TNFalpha, TNFbeta).

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Main Results:

  • Fertile women had higher levels of sex hormones, GH, and IGF-1.
  • Postmenopausal women showed significantly higher serum IL-6 and IL-18.
  • TNFalpha and TNFbeta were lower in postmenopausal women; DHEA/DHEA-S inversely correlated with IL-6/IL-18.

Conclusions:

  • Postmenopausal women display a distinct serum cytokine profile compared to fertile women.
  • The observed cytokine alterations suggest a potential shift towards Th2 lymphocyte prevalence.
  • Hormonal changes during menopause impact immune system regulation.