HPV in "carcinoma in situ" associated with HIV/AIDS infection: a case report

Annual incidence of condyloma acuminata has been reported to be high as 106.5 per 100.000, or about 0,1% of the entire population. In HIV+ individuals, HPV infection is even more prevalent 20% in HIV+ homosexual men and 27% in AIDS homosexual men). HPVDNA 16 and 18 are the most commonly found in anogenital condyloma and in 1% of pre-malignant lesions and oral cancer.

The aim of this publication is to report a clinic case of an AIDS patient with spreading condylomas in oral mucosa, one of these diagnosed as "carcinoma in situ".

A 46 year-old male diagnosed with AIDS due to a history of intestinal Mycobacterium avium, esophageal candidiasis and Citomegalovirus (CMV) retinitis. He came to our consultation as an out-patient with a healthy appearance under highly effective antiretroviral therapy (HAART). On the exploration we found spreading condylomas in all of the oral mucosa. Biopsies were performed and histological and immunohistochemical studies revealed the characteristic features of HPV infection. PCRRLFP assay was added in order to obtain a sensible typification of HPVDNA. One localization of condyloma, in the upper lip mucosa was diagnosed as "carcinoma in situ". PVDNA types 18 and 51 were confirmed. Therapy was establish with Laser carbon-dioxide application in three sessions, followed by surgical excision with electro scalpel. Carcinoma in situ required excision surgery. A local therapy was performed and follow up.

We have not find any report about HPVDNA 51 in oral "carcinoma in situ". Early detection of HPV lesions in oral mucosa is important in improving prevention of oral cancer.