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[Polymicrobial infective endocarditis in Italy].

Stefania Cicalini1, Rosa Francavilla, Katia Massaroni

  • 1Dipartimento di Malattie Infettive e Tropicali, Università La Sapienza, Roma. s.cicalini@virgilio.it

Recenti Progressi in Medicina
|March 13, 2002
PubMed
Summary

Polymicrobial infective endocarditis (IE) is rare but associated with intravenous drug abuse. Prognosis depends on infection site and specific pathogens, not necessarily the number of causative agents.

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Area of Science:

  • Infectious Diseases
  • Cardiology
  • Microbiology

Context:

  • A retrospective study analyzed 1053 cases of infective endocarditis (IE) in Italy from 1984-1999.
  • Identified 34 cases (3.2%) of IE with a polymicrobial etiology.
  • Intravenous drug abuse emerged as a significant risk factor for polymicrobial IE.

Purpose:

  • To investigate the characteristics, causative agents, and outcomes of polymicrobial infective endocarditis.
  • To compare polymicrobial IE with monomicrobial IE.
  • To identify factors influencing prognosis in polymicrobial IE.

Summary:

  • Staphylococci and Streptococci were common, often associated with Gram-negative bacteria or fungi.
  • Left-sided IE occurred in 23 patients, right-sided in 6.

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  • Twelve patients (35.3%) required surgery, and 5 (16.7%) died.

    • Impact:

    • Polymicrobial IE presents similarly to monomicrobial IE but may have specific prognostic indicators.
    • Findings highlight the importance of considering polymicrobial infections in IE, especially in intravenous drug users.
    • Prognosis is linked to the infection's location and specific microbial pathogens involved.