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A rabbit model of highkinetic one-sided pulmonary hypertension induced by Pott's operation
Wang Zhi-Ping1, Zeng Ya-Hui, Sun Pei-Wu
1Division of Cardiac Surgery, First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, #58 Zhongshang 2nd Street, Guangzhou S10080, PR China. wangzhip@public.guangzhou.gd.cn
Abstract:
This article presents a new rabbit model of pulmonary hypertension using rabbits. The left pulmonary artery of the rabbits was anastomosed on the descending aorta side-to-side and the proximal left pulmonary was banded. A portion of the arteries in the left upper lobe was ligated, and the majority of shunted blood was driven to the left middle and lower lobe. The left pulmonary hypertension was established in 86.7% of the rabbits within 1-3 months post operation and the left pulmonary hypertension was formed in all rabbits after 3 months post operation with pathological changes of pulmonary arteriole. The left pulmonary arterial pressure was higher than right pulmonary arterial pressure and the pathological changes were less evident in the right pulmonary arteriole.