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Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia
Eric W Dickson1, Stephen O Heard, Thomas E Tarara
1Department of Physiology, University of Massachusetts Medical Center, Worcester, MA 01655, USA. dicksone@ummhc.org
Objective:
To determine the efficacy of liquid ventilation using a medical-grade perfluorocarbon (perflubron) combined with parenteral or intratracheal antibiotics in a rat model of pneumonia.
Design:
Prospective, laboratory investigation.
Setting:
Experimental laboratory in a university medical center.
Subjects:
Wistar rats (n = 112).
Interventions:
One day after intratracheal inoculation with Streptococcus pneumoniae, rats received one of five experimental treatments or no treatment (control): modified liquid ventilation (MLV), intramuscular ampicillin, MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres.
Measurements And Main Results:
Animals receiving MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres had significantly improved 10-day survival rates (85%, 72%, and 72%, respectively) compared with all other groups (0% to 25%).
Conclusions:
MLV in combination with either intramuscular, intratracheal, or PulmoSpheres ampicillin improved survival as compared with MLV alone or the same dose of antibiotics delivered intramuscularly.
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