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Updated: Aug 2, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
Videofluoroscopic upper esophageal sphincter function in elderly dysphagic patients.
Katherine A Kendall1, Rebecca J Leonard
1Department of Otolaryngology, University of California, Davis, Sacramento, California 95817, USA. katherine.kendall@ucdmc.ucdavis.edu
In elderly individuals with dysphagia, the upper esophageal sphincter (UES) opening timing was prolonged but not reduced in extent. This suggests that UES dysfunction is not the primary cause of swallowing difficulties in this population.
Area of Science:
- Gerontology
- Gastroenterology
- Speech and Hearing Sciences
Background:
- Dysphagia is a common complaint among the elderly, often impacting quality of life.
- The upper esophageal sphincter (UES) plays a critical role in safe swallowing.
- Abnormalities in UES function can contribute to oropharyngeal dysphagia.
Purpose of the Study:
- To identify and characterize abnormalities in the timing and extent of upper esophageal sphincter (UES) opening.
- To investigate UES function in elderly patients experiencing dysphagia without a clear medical or surgical cause.
Main Methods:
- Retrospective review of dynamic swallowing studies in patients over 65 with dysphagia.
- Comparison of UES opening measures with young and elderly normal control groups.
- Evaluation of the relationship between UES function and other swallowing abnormalities.
Main Results:
- No reduction in the size (extent) of UES opening was observed in the dysphagic elderly group.
- UES opening timing was prolonged in patients with dysphagia.
- Prolonged UES opening correlated with impaired pharyngeal clearing, suggesting reduced pharyngeal muscle constriction.
Conclusions:
- The study found no primary abnormality in the extent or timing of upper esophageal sphincter (UES) opening in elderly patients with dysphagia.
- Dysphagia in this population may be related to other factors, such as reduced pharyngeal constriction, rather than primary UES dysfunction.
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