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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Hypertension is an independent predictor of delayed graft function and worse renal function only in kidneys with

Salvatore Di Paolo1, Giovanni Stallone, Antonio Schena

  • 1Department of Emergency and Organ Transplant, Division of Nephrology, University of Bari, Policlinico, Piazza Giulio Cesare, 11-70124 Bari, Italy.

Transplantation
|March 13, 2002
PubMed

Insights

Delayed graft function (DGF) in kidney transplants is linked to donor organ quality. Donor hypertension significantly increases DGF risk and impacts graft function, especially in suboptimal organs.

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Organ preservation

Background:

  • Delayed graft function (DGF) is a key factor in poor graft survival after cadaveric renal transplantation.
  • Risk factors and clinical predictors of DGF remain poorly understood.

Purpose of the Study:

  • To analyze risk factors for DGF, focusing on donor kidney histological damage.
  • To assess the impact of DGF and donor factors on kidney graft function in the first year post-transplant.

Main Methods:

  • Analysis of risk factors for DGF in 100 consecutive cadaveric renal transplant recipients.
  • Emphasis on histological damage in time-zero biopsies and donor characteristics.
  • Evaluation of graft function at one year post-engraftment.

Main Results:

  • Organs with DGF showed higher glomerular sclerosis, tubular atrophy, interstitial fibrosis, and vascular damage.
  • Donor hypertension was a major independent predictor of DGF (OR 19.4) in suboptimal organs (histological score >4).
  • DGF and donor hypertension adversely affected graft function at 1 year in recipients of suboptimal organs.

Conclusions:

  • Organ quality and DGF are interrelated and affect graft function via non-immune mechanisms.
  • Donor hypertension is a significant independent predictor of DGF and impacts graft function in suboptimal kidneys up to one year post-transplant.
Abstract

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