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Relation of left ventricular hypertrophy to cardiovascular complications in diabetic hypertensives

M A Ghanem Wisam1, J Murin, O Sleiman

  • 11st Department of Internal Medicine, University Hospital, Faculty of Medicine, Comenius University, Bratislava, Slovakia. Wisam_ghanem@yahoo.com

Bratislavske Lekarske Listy
|March 14, 2002
PubMed

Insights

Diabetic hypertensive patients with left ventricular hypertrophy (LVH) show worse outcomes. Echocardiography revealed LVH in 79 patients, correlating with increased heart failure, renal issues, and other cardiovascular complications.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Hypertension Research

Background:

  • Hypertension, diabetes, and atherosclerosis risk factors negatively impact patient prognosis.
  • Left ventricular hypertrophy (LVH) is a known complication of hypertension.
  • The clinical significance of LVH in diabetic hypertensive patients requires further investigation.

Purpose of the Study:

  • To compare clinical findings in diabetic hypertensive patients with and without left ventricular hypertrophy (LVH).
  • To assess the impact of LVH on the prognosis and complications in this patient group.

Main Methods:

  • Retrospective analysis of 115 hypertensive patient records from 1998-1999.
  • Diagnosis and definition of LVH using echocardiography (left ventricular mass index thresholds provided).
  • Matched comparison between LVH-positive and LVH-negative groups based on age, sex, hypertension/diabetes duration, and other risk factors.

Main Results:

  • LVH was present in 79 patients (mean age 64.6 years) and absent in 36 (mean age 63.3 years).
  • LVH-positive patients exhibited significantly higher rates of heart failure, mitral regurgitation, and renal involvement.
  • Non-significant trends indicated higher incidences of diastolic dysfunction, myocardial infarction, atrial fibrillation, and stroke in the LVH-positive group.

Conclusions:

  • Left ventricular hypertrophy significantly complicates the course of hypertension in diabetic patients.
  • Routine investigation for LVH in hypertensive individuals is recommended due to its association with a more severe disease progression.
  • Early detection and management of LVH may improve outcomes for hypertensive patients with diabetes.

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