Depolymerization of N-succinyl-chitosan by hydrochloric acid
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Updated: Oct 2, 2026

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Yoshinori Kato1, Hiraku Onishi, Yoshiharu Machida
1Department of Drug Delivery Research, Hoshi University, Tokyo, Japan. d711@hoshi.ac.jp
Abstract:
N-Succinyl-chitosan (1) was depolymerized with 7.5 M aqueous HCl at room temperature or 3.3 M aqueous HCl at 40 degrees C and the molecular weights (MW) of the products were determined by size-exclusion chromatography-multi angle light scattering (SEC-MALS) and their viscometric features were investigated. The intrinsic viscosity ([eta]) obtained at the concentration of 0.1-0.3% (w/v) in saline showed a linear relationship between log[eta] and log MW, which provided the coefficients in the Mark-Houwink equation.
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