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Related Experiment Videos

Ghrelin--not just another stomach hormone.

Guiyun Wang1, Heung Man Lee, Ella Englander

  • 1Department of Surgery, Shriners Hospitals for Children and The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0725, USA.

Regulatory Peptides
|March 14, 2002
PubMed
Summary

Ghrelin, a natural GHS-R ligand from the stomach, stimulates growth hormone (GH) secretion, appetite, and growth. This highlights a gastrointestinal-pituitary axis influencing key metabolic and growth processes.

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Gastroenterology

Background:

  • Growth hormone secretagogues (GHSs) are synthetic compounds stimulating GH secretion via the GHS-receptor (GHS-R).
  • Ghrelin, a newly identified natural ligand for GHS-R, is widely distributed in the body.
  • Stomach endocrine cells exhibit the highest ghrelin expression.

Purpose of the Study:

  • To investigate the role of ghrelin as a natural GHS and its physiological functions.
  • To explore the widespread distribution and hormonal nature of ghrelin.
  • To understand the gastrointestinal-hypothalamic-pituitary axis influenced by ghrelin.

Main Methods:

  • Identification of ghrelin as the natural ligand for the GHS-R.
  • Analysis of ghrelin and GHS-R distribution in various body tissues.

Related Experiment Videos

  • Administration of exogenous ghrelin to assess its effects on GH secretion, appetite, and body composition.

    • Main Results:

    • Ghrelin administration stimulates pituitary GH secretion, appetite, body growth, and fat deposition.
    • Ghrelin is produced in stomach and intestinal endocrine cells and is measurable in circulation, confirming its hormonal role.
    • Maximal ghrelin expression in the stomach suggests a significant role in the gastrointestinal-hypothalamic-pituitary axis.

    Conclusions:

    • Ghrelin is a major anabolic hormone with significant roles in regulating GH secretion, appetite, and body growth.
    • The stomach plays a central role in ghrelin production, influencing a gastrointestinal-hypothalamic-pituitary axis.
    • Ghrelin's activity is responsive to nutritional and caloric intake, linking digestion to hormonal regulation.