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Updated: Jul 30, 2026

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
Published on: November 29, 2016
How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2
Kenneth E Prehoda1, Wendell A Lim
1Institute of Molecular Biology, Department of Chemistry, 1229 University of Oregon, Eugene, OR 97403-1229, USA.
Abstract:
Signal transduction proteins that can integrate multiple upstream signals play a critical role in the complex regulatory circuits that control cellular behavior. The two signaling node proteins cyclin-dependent kinase 2 and the actin regulator neuronal Wiskott-Aldrich syndrome protein have qualitatively similar signaling properties. Recent studies, however, reveal that these proteins utilize distinct mechanisms of signal integration, leading to subtle but important quantitative differences in behavior.
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