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Phospholipid transfer protein.

Arie van Tol1

  • 1Department of Biochemistry, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, Rotterdam, The Netherlands. vantol@bc1.fgg.eur.nl

Current Opinion in Lipidology
|March 14, 2002
PubMed
Summary

Phospholipid transfer protein (PLTP) influences HDL levels and cholesterol metabolism. While PLTP can promote atherosclerosis, it may also offer protective effects, highlighting its complex role in cardiovascular health.

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Area of Science:

  • Lipid metabolism
  • Cardiovascular research
  • Biochemistry

Background:

  • Phospholipid transfer protein (PLTP) is recognized for its role in high-density lipoprotein (HDL) remodeling and pre-beta-HDL formation.
  • PLTP activity is elevated in conditions such as diabetes mellitus, obesity, and insulin resistance.

Purpose of the Study:

  • To investigate the multifaceted role of PLTP in HDL remodeling, VLDL turnover, and atherogenesis.
  • To explore the dual pro- and anti-atherogenic potential of PLTP in vivo.
  • To summarize current understanding of PLTP's function in human (patho)physiology.

Main Methods:

  • Over-expression of human PLTP in C57BL6 mice.
  • Analysis of PLTP knockout mice models.
  • Assessment of atherosclerosis development in transgenic mouse models bred into PLTP knockout mice.

Main Results:

  • Over-expression of PLTP in mice led to lower plasma HDL levels, likely due to increased HDL catabolism.
  • Despite reduced HDL, plasma from PLTP-overexpressing mice showed reduced macrophage cholesterol accumulation and enhanced pre-beta-HDL formation.
  • PLTP was found to be pro-atherogenic in certain models but demonstrated anti-atherogenic potential in wild-type mice.

Conclusions:

  • PLTP plays a complex role in lipid metabolism, influencing both HDL and VLDL pathways.
  • PLTP exhibits context-dependent effects on atherogenesis, acting as both a risk factor and a protective agent.
  • Further research is needed to fully elucidate PLTP's role and regulation in human health and disease.

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