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Related Experiment Videos

"Positive" bone scan--a contraindication to surgery?

G T Basinger, D L McCullough, A P McLaughlin

    Urology
    |November 1, 1975
    PubMed
    Summary
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    A positive technetium-99m bone scan in urologic cancer patients may not indicate metastatic disease. Bone biopsy can confirm negative results, preventing unnecessary withholding of curative therapy.

    Area of Science:

    • Oncology
    • Nuclear Medicine
    • Diagnostic Imaging

    Background:

    • Bone scans using technetium-99m are common for detecting metastatic disease in cancer patients.
    • Abnormal findings on bone scans can influence treatment decisions, potentially leading to the withholding of curative therapies.

    Purpose of the Study:

    • To evaluate the significance of abnormal technetium-99m bone scans as the sole indicator of metastatic disease in urologic cancer.
    • To determine if bone biopsy is warranted when a bone scan is the only evidence of metastasis.

    Main Methods:

    • Retrospective review of eleven urologic cancer patients with abnormal technetium-99m bone scans.
    • Correlation of bone scan findings with subsequent bone biopsy results in cases where biopsy was performed.

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    Main Results:

    • In eleven patients, an abnormal technetium-99m bone scan was the only evidence suggesting metastatic disease.
    • Histological examination of bone biopsy samples in selected cases proved negative for tumor, despite positive scan findings.

    Conclusions:

    • A positive technetium-99m bone scan should not be the sole basis for withholding potentially curative therapy in urologic cancer.
    • Bone biopsy is a valuable tool to histologically confirm or refute metastatic disease when bone scan findings are equivocal or the only positive evidence.