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99m Tc-ciprofloxacin (Infecton) imaging in the diagnosis of knee prosthesis infections

M J Larikka1, A K Ahonen, O Niemelä

  • 1LP Central Hospital Laboratory, Kemi, Finland. Martti.Larikka@lpshp.fi

Nuclear Medicine Communications
|March 14, 2002
PubMed

Insights

Technetium-99m labelled ciprofloxacin imaging effectively detects knee prosthesis infections. Infected prostheses show distinct, persistent uptake on 24-hour scans, aiding diagnosis.

Area of Science:

  • Nuclear Medicine
  • Orthopedic Surgery
  • Infectious Diseases

Background:

  • Knee prosthesis infections pose significant diagnostic challenges.
  • Accurate detection is crucial for timely and effective treatment.
  • Novel imaging techniques are needed to improve diagnostic accuracy.

Purpose of the Study:

  • To assess the utility of 99mTc-labelled ciprofloxacin imaging for diagnosing knee prosthesis infections.
  • To determine the sensitivity and specificity of this imaging modality.

Main Methods:

  • 16 patients with symptomatic knee prostheses were evaluated.
  • 99mTc-ciprofloxacin SPECT/CT imaging was performed at 1, 4, and 24 hours post-injection.
  • Imaging findings were correlated with clinical and microbiological data.

Main Results:

  • Infected knee prostheses exhibited more intensive, focal uptake of 99mTc-ciprofloxacin, often extending beyond the synovial cavity.
  • Non-specific uptake in non-infected joints faded by 24 hours, while infection-related uptake remained visible.
  • Diagnostic sensitivity was 86% and specificity was 78% for detecting infection.

Conclusions:

  • 99mTc-ciprofloxacin imaging is a valuable tool for diagnosing knee prosthesis infections.
  • Persistent, focal uptake outside the synovial cavity on 24-hour scans is indicative of infection.
  • This imaging modality can aid clinicians in differentiating infected from non-infected prosthetic joints.

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