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Hans Ussing, experiments and models.

B Lindemann1

  • 1Department of Physiology, Universität des Saarlandes, D-66421 Homburg, Germany.

The Journal of Membrane Biology
|March 14, 2002
PubMed
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Hans H. Ussing pioneered epithelial physiology with his transport model. This foundational work, particularly the KJU-model, explains complex epithelial functions and inspires ongoing research on ion channels.

Area of Science:

  • Physiology
  • Cell Biology
  • Biophysics

Background:

  • Hans H. Ussing, a pivotal figure in epithelial physiology, developed a groundbreaking model for understanding epithelial transport.
  • His work demonstrated how complex physiological functions can emerge from simple, fundamental principles.

Discussion:

  • The KJU-model, initially developed for amphibian epidermis in 1958, was later adapted for various epithelia.
  • The model is particularly relevant for epithelia expressing amiloride-sensitive sodium channels in their apical membrane.

Key Insights:

  • Ussing's model provided an early and elegant framework for epithelial transport mechanisms.
  • The research highlights the enduring impact of Ussing's conceptual approach on the field.

Outlook:

Related Experiment Videos

  • Subsequent research has built upon Ussing's work, investigating sodium channels and their cellular contexts.
  • Ussing's principles continue to inspire and guide researchers in epithelial physiology.