Related Experiment Video
Updated: Aug 2, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
Published on: January 26, 2015
Mechanisms of eosinophil recruitment and activation
Darryl Adamko1, Paige Lacy, Redwan Moqbel
1Department of Medicine, University of Alberta, 550A HMRC, Edmonton, AB T6G 2S2, Canada.
Abstract:
The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recent developments in research on many organ systems have provided novel insights into the possible underlying role of the eosinophil in both allergic and nonallergic inflammation. This review examines the pathways associated with eosinophil recruitment and activation and discusses these findings, with reference to clinically defined categories.
More Related Videos
10:39Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
03:23Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Related Concept Videos
Inflammation
Chemotaxis and Direction of Cell Migration
Activation of Integrins
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Acute Inflammation II: Cellular Phase