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UK-315716/UK-240455. Pfizer
1GlaxoSmithKline, Medicines Research Centre, Chemistry Dept, Verona, Italy.
Abstract:
Pfizer is developing the atropoisomeric quinoxalinediones, UK-315716 and UK-240255, from a series of NMDA/glycine antagonists for the potential treatment of stroke. Both are compounds are undergoing clinical trials. UK-315716 has improved aqueous solubility and in vivo efficacy over UK-240455, and a lower projected clinical dose of 200 mg compared to 500 mg with UK-240455.

