Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biomimetic selectivity.

R Breslow1

  • 1Department of Chemistry, Columbia University, Chandler Laboratory, New York, New York 10027, USA. rb33@columbia.edu

Chemical Record (New York, N.Y.)
|March 15, 2002
PubMed
Summary

Biomimetic chemistry imitates enzymes to control chemical reactions. Researchers developed a cytochrome P-450 mimic for selective steroid hydroxylation, guided by catalyst-substrate geometry.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Length-dependent thermopower of highly conducting Au-C bonded single molecule junctions.

Nano letters·2013
Same author

Probing the conductance superposition law in single-molecule circuits with parallel paths.

Nature nanotechnology·2012
Same author

Catalytic hydrolysis of a phosphate triester by tetracoordinated zinc complexes.

Journal of the American Chemical Society·2011
Same author

Catalytic directed steroid chlorination with billion-fold turnovers.

Journal of the American Chemical Society·2011
Same author

In situ formation of highly conducting covalent Au-C contacts for single-molecule junctions.

Nature nanotechnology·2011
Same author

Plasmonic control of the shape of the Raman spectrum of a single molecule in a silver nanoparticle dimer.

ACS nano·2009

Area of Science:

  • Synthetic organic chemistry
  • Biomimetic chemistry
  • Enzymatic catalysis

Background:

  • Traditional synthetic chemistry relies on substrate reactivity for selectivity.
  • Enzymatic selectivity is governed by enzyme-substrate complex geometry, overriding intrinsic reactivity.
  • Biomimetic chemistry seeks to replicate enzymatic selectivity principles.

Purpose of the Study:

  • To explore biomimetic approaches for achieving high selectivity in chemical synthesis.
  • To develop catalysts that mimic enzymatic control over reactivity.
  • To investigate the role of catalyst-substrate geometry in directing chemical transformations.

Main Methods:

  • Utilized a biomimetic catalyst designed to imitate cytochrome P-450.
  • Applied the catalyst to achieve selective hydroxylation of steroid molecules.
  • Investigated the influence of catalyst-substrate complex geometry on reaction outcomes.

Main Results:

  • Achieved highly selective hydroxylation of steroids.
  • Demonstrated that catalyst-substrate geometry completely dominated selectivity, overriding normal reactivity.
  • Successfully mimicked the geometric control principle of enzymatic catalysis.

Conclusions:

  • Biomimetic catalysts can effectively replicate enzymatic selectivity.
  • Geometric control within catalyst-substrate complexes is a powerful strategy for selective synthesis.
  • This approach offers a new paradigm for designing selective synthetic methodologies.

Related Experiment Videos