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Synthesis of marine sponge bisindole alkaloids dihydrohamacanthins
Fumiko Y Miyake1, Kenichi Yakushijin, David A Horne
1Oregon State University, Department of Chemistry, Corvallis, Oregon 97331, USA.
Organic Letters
|March 15, 2002
Abstract:
[structure: see text] A convergent synthesis of the marine sponge bisindole alkaloids dihydrohamacanthins is described. The synthesis centers on the construction of 3,5- and 3,6-linked pyrazinones and their reduction to the requisite piperazinones with sodium cyanoborohydride.