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Updated: Aug 9, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?
1Howard Hughes Medical Institute, University of Michigan Medical Center, 1150 W. Medical Center Dr., Ann Arbor, MI 48109-0650, USA. yurii@umich.edu
Abstract:
A new subfamily of two-domain histone acetyltransferases (HATs) related to Elp3 has been identified. In addition to a HAT domain in the C terminus, these proteins have an N-terminal domain similar to the catalytic domain of S-adenosylmethionine radical enzymes. Two-domain organization is preserved in evolution, suggesting that both enzymatic activities are functionally or mechanistically coupled and directed towards highly conserved substrates. The functional implications of this similarity and a possible role for Elp3-related proteins as histone demethylases are discussed.
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