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Soluble complement receptor type 1 protects rats from lethal shock induced by anti-Crry antibody following
Masashi Mizuno1, Kazuhiro Nishikawa, Noriko Okada
1Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
Background:
In rats primed with a trace amount of lipopolysaccharide (LPS), acute lethal shock is induced following the injection of monoclonal antibody against a membrane inhibitor of complement (anti-Crry). Administration of cobra venom factor to exhaust complement before the LPS priming can prevent the lethal reaction. Therefore, we evaluated whether soluble complement receptor type 1 (sCR1), which inhibits complement reaction, can interfere with lethal shock when administered after LPS priming or even after anti-Crry injection.
Methods:
sCR1 was administered intravenously before or after the administration of anti-Crry, and the effects on blood pressure and acute lethality were determined.
Results:
Administration of sCR1 could rescue rats from lethal shock even when it was administered after anti-Crry injection, which immediately causes a blood pressure decrease leading to lethal shock.
Conclusion:
sCR1 may be an effective treatment for acute shock involving complement activation.