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[Amniotic membrane graft in ocular surface disease. Prospective study with 31 cases]
M Muraine1, G Descargues, O Franck
1Service d'ophtalmologie, Hôpital Charles Nicolle. Marc.Muraine@chu-rouen.fr
Journal Francais D'Ophtalmologie
|March 16, 2002
Summary
Amniotic membrane transplantation effectively treats persistent corneal ulcers and symblepharons, offering a simple surgical option for ocular surface disease. While not a cure-all, it shows promise as a preliminary treatment before more complex procedures.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Tissue Engineering
Context:
- Amniotic membrane possesses unique properties beneficial for ocular surface reconstruction.
- Its application in treating various ocular pathologies has been explored.
- This study investigates its efficacy in a prospective patient cohort.
Purpose:
- To evaluate the outcomes of amniotic membrane grafting in diverse ocular surface diseases.
- To assess the success rates and limitations of this therapeutic approach.
Summary:
- Amniotic membrane grafts were applied to 31 eyes across five groups: chronic ulcers, severe ulcers, corneal burns, bullous dystrophies, and symblepharons.
- Success rates varied, with the highest efficacy observed in persistent trophic ulcers (80%) and symblepharon reconstruction (75%).
- Limitations included graft failure in severe corneal burns and bullous dystrophies when not confined to the limbus.
Impact:
- Amniotic membrane grafting is a valuable, simple surgical technique for ocular surface disease management.
- It shows particular promise for persistent corneal ulcers and symblepharons, potentially serving as a precursor to stem cell transplantation.
- Further clarification of indications is needed, especially in cases of limbal stem cell destruction.