Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunonutrition in patients after multiple trauma.

L Bastian1, A Weimann

  • 1Unfallchirurgische Klinik, Medizinische Hochschule, Hannover, Germany. bastian.leonard@mh-hannover.de

The British Journal of Nutrition
|March 16, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

German guidelines for the diagnosis and treatment of squamous-cell carcinoma and adenocarcinoma of the esophagus-version 4.0.

ESMO gastrointestinal oncology·2026
Same author

Individual multimodal prehabilitation in high-risk patients undergoing major abdominal surgery following neoadjuvant treatment - a feasibility study.

Langenbeck's archives of surgery·2025
Same author

Quality-of-care standards in adult type 3 intestinal failure caused by benign disease: A European society of clinical nutrition and metabolism (ESPEN) position paper.

Clinical nutrition ESPEN·2024
Same author

[S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

[S3 guideline sepsis-prevention, diagnosis, treatment, and aftercare : Summary of the strong recommendations].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

[Geriatric emergencies].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020

Immunonutrition, a specialized enteral feeding, significantly reduces systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF) in severe trauma patients. This approach improves immune function and clinical outcomes, lowering hospital costs.

Area of Science:

  • Trauma critical care
  • Immunonutrition
  • Inflammatory response modulation

Background:

  • Severe trauma triggers life-threatening immunological dysregulation.
  • Inflammatory and infectious complications, including sepsis and multiple organ failure (MOF), have high mortality rates.
  • Gut-associated lymphoid tissue (GALT) immune response changes contribute to intestinal dysfunction and sepsis susceptibility.

Purpose of the Study:

  • To evaluate the efficacy of immunonutrition in mitigating the early hyperinflammatory phase post-trauma.
  • To reduce the incidence of sepsis and multiple organ failure (MOF) in severe trauma patients.
  • To assess the impact of immunonutrition on clinical outcomes and hospital costs.

Main Methods:

  • Prospective, randomized, double-blind, controlled study.

Related Experiment Videos

  • Inclusion of twenty-nine severe trauma patients.
  • Intervention with enteral feeding supplemented with arginine, n-3-polyunsaturated fatty acids, and nucleotides (immunonutrition).

    • Main Results:

    • Significant reduction in systemic inflammatory response syndrome (SIRS) days per patient.
    • Lowered multiple organ failure (MOF) scores on days 3 and 8-11 (P<0.05).
    • Reported reductions in septic complications, MOF rates, and hospital stay.

    Conclusions:

    • Early immunomodulatory intervention via enteral feeding is crucial within 72 hours post-injury.
    • Immunonutrition is a rational strategy to improve immune function and reduce septic complications in critically ill or injured patients.
    • Improved clinical outcomes associated with immunonutrition translate to reduced hospital costs.