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Related Experiment Videos

n-3 fatty acids in psoriasis.

P Mayser1, H Grimm, F Grimminger

  • 1Department of Dermatology and Andrology, Justus Liebig University, Giessen, Germany. Peter.Mayser@derma.med.uni-giessen.de

The British Journal of Nutrition
|March 16, 2002
PubMed
Summary

Intravenous fish oil, rich in eicosapentaenoic acid (EPA), effectively treats psoriasis by altering inflammatory eicosanoid generation. This approach offers a faster therapeutic response compared to oral supplements.

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Area of Science:

  • Dermatology
  • Biochemistry
  • Nutrition

Background:

  • Psoriasis is linked to increased free arachidonic acid (AA) and its inflammatory metabolites.
  • Alternative polyunsaturated fatty acids (PUFA), like eicosapentaenoic acid (EPA), may offer therapeutic benefits by competing with AA.
  • Previous studies on oral fish oil for psoriasis showed conflicting, non-dose-dependent results.

Purpose of the Study:

  • To evaluate the efficacy and safety of an intravenously administered fish oil lipid emulsion for treating psoriasis.
  • To compare the therapeutic effects of n-3 fatty acids (EPA) versus n-6 fatty acids (AA) in psoriasis patients.
  • To investigate the impact of intravenous n-3 fatty acids on inflammatory eicosanoid production.

Main Methods:

  • Three studies were conducted using daily intravenous infusions of either an n-3 fatty acid-based lipid emulsion (Omegaven) or a conventional n-6 lipid emulsion (Lipoven).
  • Patients received different time and dose regimens.
  • Clinical psoriasis course, neutrophil 5-lipoxygenase (LO) products of EPA and AA, thromboxane (TX) B2/B3, PAF, and plasma free fatty acids were analyzed.

Main Results:

  • Intravenous n-3 fatty acid treatment showed a considerably higher response rate in psoriasis patients compared to n-6 lipid infusions.
  • A significant increase (over 10-fold) in neutrophil EPA-derived 5-LO product formation was observed in the n-3 group.
  • Rapid increases in plasma-free EPA were noted within the first days of n-3 lipid infusion.

Conclusions:

  • Intravenous administration of n-3 fatty acids effectively reduces psoriasis.
  • The therapeutic effect may be linked to altered inflammatory eicosanoid generation.
  • The rapid response to intravenous n-3 lipids significantly surpasses the kinetics observed with oral supplementation.

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