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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Glutamine supplementation in bone marrow transplantation.

Thomas R Ziegler1

  • 1Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. tzieg01@emory.edu

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Supplementing with the amino acid glutamine may benefit patients undergoing bone marrow transplantation (BMT) by aiding protein anabolism and supporting gut and immune cells. Further research is needed to confirm its efficacy with current BMT protocols.

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Area of Science:

  • Clinical Nutrition
  • Metabolic Support
  • Amino Acid Therapy

Background:

  • Glutamine is crucial for gut and immune cells, acting as a primary fuel source.
  • Evidence from animal models and clinical studies suggests glutamine's benefits in catabolic states.
  • Patients undergoing bone marrow transplantation (BMT) often experience protein wasting, gut injury, and immunodeficiency.

Purpose of the Study:

  • To evaluate the efficacy and safety of glutamine supplementation in patients undergoing BMT.
  • To explore glutamine's potential as adjunctive metabolic support in BMT recipients.

Main Methods:

  • Review of clinical investigations on enteral and parenteral glutamine supplementation.
  • Analysis of data from studies involving chemotherapy, trauma, sepsis, and BMT.

Main Results:

  • Glutamine supplementation is generally well-tolerated in patients receiving high-dose chemotherapy or BMT.
  • Some studies indicate potential benefits, including protein-anabolic effects and support for gut and immune function.
  • Not all studies have demonstrated significant benefits, highlighting variability in outcomes.

Conclusions:

  • Glutamine supplementation shows promise as adjunctive metabolic support for select BMT patients.
  • Further randomized, double-blind, controlled trials are essential to establish glutamine's efficacy with modern BMT regimens.
  • Continued research is necessary due to the evolving nature of BMT protocols.