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Scrofuloderma and Sweet's syndrome
Punkae Mahaisavariya1, Angkana Chaiprasert, Jane Manonukul
1Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok, Thailand.
International Journal of Dermatology
|March 16, 2002
Summary
Nontuberculous mycobacterial infections can cause scrofuloderma, a skin condition. This study found an association between these infections and Sweet's syndrome, particularly in middle-aged women with cervical lymphadenitis.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Sweet's syndrome is rarely associated with nontuberculous mycobacterial lymphadenitis.
- This study investigates the clinical, demographic, and bacteriologic aspects of scrofuloderma caused by nontuberculous mycobacteria.
Purpose of the Study:
- To report on 18 patients with scrofuloderma and scrofuloderma-like conditions due to nontuberculous mycobacterial infections.
- To analyze the association with Sweet's syndrome in these patients.
Main Methods:
- Histopathologic and microbiologic examination of biopsy specimens from 18 patients.
- Exclusion of deep fungal infections.
- Treatment with antimicrobials or antituberculous drugs based on causative species.
Main Results:
- 18 cases of scrofuloderma were identified among 104 patients with cutaneous mycobacterial infections.
- 16 cases were linked to underlying lymphadenitis, predominantly in the cervical region.
- Five patients experienced recurrent Sweet's syndrome, often middle-aged women with cervical lymphadenitis caused by rapid-growing mycobacteria.
Conclusions:
- Age, sex, and infection site may influence the occurrence of Sweet's syndrome in nontuberculous mycobacterial infections.
- Further research is needed to elucidate the relationship between these conditions.