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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Hodgkin's lymphoma: the pathologist's viewpoint
S A Pileri1, S Ascani, L Leoncini
1Pathologic Anatomy and Haematopathology, Bologna University, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy. pileri@almadns.unibo.it
Journal of Clinical Pathology
|March 16, 2002
Summary
Recent Hodgkin
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Hodgkin's lymphoma (HL) research has advanced understanding of its phenotype, molecular features, and lymphomagenesis.
- Consensus exists on B cell origin in most HL cases, with Epstein-Barr virus and defective cytokinesis implicated in some patients.
- The REAL/WHO classification distinguishes lymphocyte predominance HL (LP-HL) from classic HL (CHL) subtypes based on clinical, morphological, and molecular differences.
Purpose of the Study:
- To elucidate the updated understanding of Hodgkin's lymphoma phenotype, molecular characteristics, and lymphomagenesis.
- To clarify the classification and distinctions between Hodgkin's lymphoma subtypes and related lymphomas.
- To explore the development of tailored treatments based on tumor pathobiology.
Main Methods:
- Review of recent research on Hodgkin's lymphoma phenotype and molecular characteristics.
- Analysis of classification systems (REAL/WHO) for Hodgkin's lymphoma subtypes.
- Evaluation of proposed treatment strategies adjusted to tumor pathobiology.
Main Results:
- Established B cell derivation in most Hodgkin's lymphoma cases.
- Identified Epstein-Barr virus and defective cytokinesis as relevant factors in a subset of patients.
- Refined distinctions between classic HL subtypes and clarified boundaries with other lymphomas like anaplastic large cell lymphoma and T cell rich B cell lymphoma.
Conclusions:
- Hodgkin's lymphoma understanding has significantly advanced, revealing B cell origins and key pathogenetic factors.
- The classification system effectively differentiates HL subtypes, though some distinctions remain challenging.
- Personalized treatment strategies for Hodgkin's lymphoma are emerging, tailored to specific pathobiological features.
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