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Localized melanosis in an immunocompromised patient with local metastatic melanoma
Marc R Carruth1, Glenn D Goldstein, Donald K Tillman
1Skin and Mohs Surgery Center, Kansas City, Missouri, USA.
Background:
Melanosis is a rare, but well recognized late complication of some cases of metastatic melanoma. The precise pathogenesis is unclear. Most described cases report diffuse metastases and diffuse melanosis.
Objective:
To present a case of localized melanosis secondary to locally metastatic melanoma without evidence of systemic involvement in a renal transplant patient.
Methods:
Case report and literature review.
Results:
We describe a case of localized melanosis in an immunocompromised patient without evidence of systemic metastases. The patient underwent limb perfusion and her immunosuppressive therapy has been stopped. The melanosis has not regressed; however, there has been no systemic involvement and her transplanted kidney is still functioning well.
Conclusion:
To our knowledge this is the first report of this phenomenon in an immunocompromised host.