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Progressive cerebral atrophy in multiple system atrophy.

Masaaki Konagaya1, Yoko Konagaya, Motoko Sakai

  • 1Department of Neurology, Suzuka National Hospital, 3-2-1 Kasado, Mie 513-8501, Suzuka, Japan. konagaya@suzuka.hosp.go.jp

Journal of the Neurological Sciences
|March 19, 2002
PubMed
Summary

Multiple system atrophy (MSA) causes progressive brain atrophy, particularly in the frontal and temporal lobes. MRI studies reveal significant cerebral hemisphere involvement, especially in the frontal lobe, in MSA patients.

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Area of Science:

  • Neurology
  • Neuroimaging
  • Pathology

Background:

  • Multiple system atrophy (MSA) is a progressive neurodegenerative disorder.
  • Cerebral hemispheric involvement in MSA is not fully understood.
  • MRI is a key tool for assessing brain structure changes.

Purpose of the Study:

  • To investigate cerebral hemispheric involvement in multiple system atrophy (MSA) using MRI.
  • To quantify the progression of brain atrophy in MSA patients.
  • To correlate MRI findings with pathological examination in autopsied cases.

Main Methods:

  • MRI scans were performed on nine MSA patients and 85 healthy controls.
  • Measurements of cerebral hemisphere and lobe volumes relative to intracranial volume were taken.

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  • Autopsy findings from five MSA patients were analyzed for pathological changes.

    • Main Results:

    • Significant progression of atrophy was observed in the cerebrum, frontal, and temporal lobes of MSA patients.
    • Frontal lobe atrophy was a prominent finding, with some cases showing remarkable degeneration.
    • Pathological examination revealed frontal lobe atrophy, gliosis, demyelination, and glial cytoplasmic inclusions (GCIs).

    Conclusions:

    • The cerebral hemisphere, particularly the frontal lobe, is significantly involved in multiple system atrophy (MSA).
    • MRI findings demonstrate progressive atrophy in key brain regions affected by MSA.
    • Pathological evidence supports the observed MRI findings of frontal lobe degeneration in MSA.