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The zebrafish as a model system for human disease.

Alister C Ward1, Graham J Lieschke

  • 1Centre for Cellular & Molecular Biology, School of Biological & Chemical Sciences, Deakin University, Burwood, Victoria, Australia. award@deakin.edu.au

Frontiers in Bioscience : a Journal and Virtual Library
|March 19, 2002
PubMed
Summary

Zebrafish (Danio rerio) models are advancing developmental biology and human disease research. These models help identify genes and functions, offering insights into human pathophysiology.

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Area of Science:

  • Developmental biology
  • Genomics
  • Human disease modeling

Background:

  • Zebrafish (Danio rerio) are established models in developmental biology.
  • Genomic infrastructure is enhancing zebrafish utility for disease research.

Purpose of the Study:

  • To review zebrafish applications in identifying novel genes.
  • To describe zebrafish use in assigning gene function.
  • To highlight zebrafish contributions to understanding human pathophysiology.

Main Methods:

  • Utilizing sophisticated cellular and molecular approaches in zebrafish.
  • Leveraging genomic infrastructure for disease modeling.
  • Reviewing case studies of gene discovery and functional assignment.

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Main Results:

  • Zebrafish models facilitate the identification of novel genes.
  • Functional genomics in zebrafish provides insights into gene roles.
  • Zebrafish studies offer valuable clues to human disease mechanisms.

Conclusions:

  • Zebrafish are powerful models for genetic and functional studies.
  • Zebrafish research accelerates the understanding of human pathophysiology.
  • The integration of genomics enhances zebrafish's role in biomedical research.