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Update on thiol status and supplements in physical exercise.

C K Sen1

  • 1Laboratory of Molecular Medicine, Department of Surgery, 512 Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA.

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee
|March 19, 2002
PubMed
Summary

Strenuous exercise increases reactive oxygen species, indicated by glutathione oxidation. Antioxidant supplements can help manage this, but oxidants also play regulatory roles in cells.

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Area of Science:

  • Biochemistry
  • Cellular Biology
  • Exercise Physiology

Background:

  • Strenuous exercise elevates reactive oxygen species (ROS) production.
  • Tissue glutathione oxidation is a key indicator of exercise-induced ROS.
  • Cellular thiols are vital for antioxidant defense and redox signaling.

Purpose of the Study:

  • To update the understanding of cellular thiols and thiol antioxidants.
  • To review the dual role of oxidants as damaging agents and signaling molecules.

Main Methods:

  • Literature review of cellular thiols and antioxidant functions.
  • Analysis of studies on exercise-induced oxidative stress.
  • Examination of the role of oxidants in cellular signaling pathways.

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Main Results:

  • Exercise rapidly induces blood glutathione oxidation in humans.
  • Antioxidant supplementation can modulate exercise-induced glutathione oxidation.
  • Oxidants, beyond causing damage, act as crucial cellular messengers.

Conclusions:

  • Cellular thiols are essential for antioxidant defense and redox regulation.
  • Lipoic acid shows promise as a thiol antioxidant supplement.
  • The biological significance of oxidants requires re-evaluation due to their signaling roles.