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Related Experiment Videos

Sport nutritional supplements: quality and doping controls.

C Ayotte1, J F Lévesque, M Clé roux

  • 1INRS-Institut Armand-Frappier, Pointe-Claire, QC.

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee
|March 19, 2002
PubMed
Summary

Many nutritional supplements contain undeclared prohibited substances. Detecting synthetic steroids requires analyzing metabolic profiles, not just substance identification, to ensure fair competition for athletes.

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Area of Science:

  • Sports Science
  • Analytical Chemistry
  • Pharmacology

Background:

  • Athletes frequently use nutritional supplements, some containing undeclared prohibited substances like androgens and pro-hormones.
  • Limited clinical studies exist on the efficacy and adverse effects of these commonly used performance-enhancing substances.
  • Detection of natural steroids like testosterone is challenging due to potential for misinterpretation of metabolic profiles.

Purpose of the Study:

  • To investigate methods for detecting prohibited substances in nutritional supplements used by athletes.
  • To differentiate between natural and synthetic steroid origins in athletes' urine samples.
  • To establish reliable analytical approaches for anti-doping efforts.

Main Methods:

  • Analysis of nutritional supplement contents for undeclared prohibited substances.

Related Experiment Videos

  • Gas Chromatography-Mass Spectrometry (GC/MS) and Gas Chromatography-Combustion-Isotope Ratio Mass Spectrometry (GC/C/IRMS) for steroid analysis.
  • Evaluation of urinary metabolic profiles and individual norms to detect deviations.

    • Main Results:

    • Some supplements contained unlisted prohibited substances (ephedrine, caffeine, steroids), leading to positive urine tests.
    • Identification of specific urinary steroids alone is insufficient to prove administration of natural testosterone precursors.
    • Deviations in metabolic profiles, compared to individual norms, are key indicators of synthetic steroid use.

    Conclusions:

    • Accurate detection of doping requires advanced analytical techniques beyond simple substance identification.
    • GC/MS and GC/C/IRMS are powerful tools for distinguishing natural from synthetic steroids in athletes.
    • Anti-doping strategies must account for complex metabolic profiles to ensure fair play.