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Related Experiment Videos

Protein intake and bone growth.

J P Bonjour1, P Ammann, T Chevalley

  • 1Division of Bone Diseases, WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland.

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee
|March 19, 2002
PubMed
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Adequate protein intake is crucial for bone development and achieving peak bone mass. Insufficient protein, especially during childhood, can negatively impact bone health and increase osteoporosis risk later in life.

Area of Science:

  • Nutritional Science
  • Pediatric Endocrinology
  • Bone Biology

Background:

  • Proteins are vital osteotrophic nutrients influencing peak bone mass.
  • Protein malnutrition during development elevates risks for osteoporosis and fragility fractures.
  • Low protein intake negatively affects bone mass acquisition and conservation.

Purpose of the Study:

  • To investigate the association between protein intake and bone mass gain in children and adolescents.
  • To understand the role of protein in skeletal development and Insulin-like Growth Factor-I (IGF-I) action.
  • To identify critical periods for protein's impact on bone health.

Main Methods:

  • Review of animal and human studies on protein intake and bone health.
  • Analysis of the relationship between dietary protein and bone mineral density in healthy children and adolescents.

Related Experiment Videos

  • Examination of protein's influence on Insulin-like Growth Factor-I (IGF-I) pathways.

    • Main Results:

    • A positive correlation exists between protein intake and bone mass gain in both sexes across multiple skeletal sites.
    • This association is particularly significant in prepubertal children.
    • Low protein intake impairs the production and action of IGF-I, essential for bone growth and mineralization.

    Conclusions:

    • Protein is a key nutrient for optimal skeletal development and achieving peak bone mass.
    • The skeletal response to protein intake is heightened during the pre-pubertal period.
    • Ensuring adequate protein consumption during childhood and adolescence is critical for long-term bone health and osteoporosis prevention.