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Related Experiment Videos

Antiphospholipid antibodies and infertility.

May Backos1, Raj Rai, Lesley Regan

  • 1Department of Reproductive Science and Medicine, Imperial College School of Medicine at St Mary's Hospital, London W2 1NY, UK.

Human Fertility (Cambridge, England)
|March 19, 2002
PubMed
Summary

Routine screening for antiphospholipid antibodies (aPL) is not recommended for women undergoing in vitro fertilization and embryo transfer (IVF-ET). Studies show aPL do not significantly impact IVF-ET success rates, despite higher prevalence in infertile women.

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Area of Science:

  • Reproductive Immunology
  • Assisted Reproductive Technologies

Background:

  • Antiphospholipid antibodies (aPL) are linked to recurrent pregnancy loss.
  • Defective embryonic implantation connects infertility and miscarriage.
  • The role of aPL in IVF-ET implantation failure is under investigation.

Purpose of the Study:

  • To review evidence on aPL screening in women undergoing IVF-ET.
  • To determine if aPL testing is warranted for IVF-ET patients.

Main Methods:

  • Critical review of published data.
  • Analysis of prospective studies on aPL and IVF-ET outcomes.

Main Results:

  • Most studies report increased aPL prevalence in women undergoing IVF-ET.

Related Experiment Videos

  • Prospective studies show aPL do not significantly affect implantation or pregnancy rates in IVF-ET.
  • Increased aPL prevalence in infertility may indicate generalized autoimmune disturbance.

    • Conclusions:

    • Routine aPL screening is not recommended for women undergoing IVF-ET.
    • Therapeutic interventions for aPL in IVF-ET should be reserved for randomized controlled trials.