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[Tetanus immunity during senescence (author's transl)].

H Finger, E Habermann, K Bracharz

    Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Praventive Medizin
    |October 1, 1975
    PubMed
    Summary

    Antibody levels against tetanus toxoid were low in older adults, with men showing better protection than women. However, vaccination can still induce strong immunity in the elderly.

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    Toxicon : official journal of the International Society on Toxinology·1995

    Area of Science:

    • Immunology
    • Gerontology

    Context:

    • Assessing humoral immunity in aging populations is crucial for public health.
    • Tetanus toxoid antibody levels are a key indicator of vaccine-induced protection.

    Purpose:

    • To evaluate the circulating antibody concentrations against tetanus toxoid in individuals aged 60-98 years.
    • To determine the prevalence of protective immunity and assess the impact of active immunization in the elderly.

    Summary:

    • Antibody levels against tetanus toxoid were measured in 2554 elderly individuals (60-98 years) using mouse protection tests and radioimmunoassay.
    • Only 15.3% of participants demonstrated protective immunity (≥0.01 IU/ml).
    • Men exhibited higher protection rates than women, and active immunization successfully induced robust immunity even in senescence.

    Impact:

    • Highlights potential gaps in tetanus immunity among the elderly, suggesting a need for booster vaccinations.
    • Demonstrates the efficacy of tetanus vaccination in older adults, emphasizing the importance of continued immunization strategies.
    • Provides valuable data for public health policies concerning vaccination schedules for geriatric populations.

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