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Antiproliferative action of vitamin D
Timo Ylikomi1, Ilkka Laaksi, Yan-Ru Lou
1Graduate School of Biomedicine, Department of Cell Biology, 33014 University of Tampere, Finland.
Abstract:
During the past few years, it has become apparent that vitamin D may play an important role in malignant transformation. Epidemiological studies suggest that low vitamin D serum concentration increases especially the risk of hormone-related cancers. Experimentally, vitamin D suppresses the proliferation of normal and malignant cells and induces differentiation and apoptosis. In the present review we discuss the mechanisms whereby vitamin D regulates cell proliferation and whether it could be used in prevention and treatment of hyperproliferative disorders like cancers.
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