Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis

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  • 1Department of Neurology, Fairview Multiple Sclerosis Center and University of Minnesota, 701 25th Ave. South, #200, Minneapolis, MN 55454, USA. Schap003@umn.edu

Current Neurology and Neuroscience Reports
|March 20, 2002
PubMed

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Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...