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Role of the mannose receptor in the immune response

V Apostolopoulos1, I F McKenzie

  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. v.apostolopoulos@ari.unimelb.edu.au

Current Molecular Medicine
|March 20, 2002
PubMed

Insights

The mannose receptor (MR) is crucial for host defense, bridging innate and adaptive immunity. This review explores its role in recognizing microbes and mediating immune responses.

Area of Science:

  • Immunology
  • Microbiology

Background:

  • The mannose receptor (MR) recognizes microbial carbohydrates.
  • MR is expressed on macrophages and dendritic cells.
  • MR mediates endocytosis and phagocytosis.

Purpose of the Study:

  • Review the MR's role in innate host defense.
  • Summarize evidence for MR's role in adaptive immunity.

Main Methods:

  • Literature review of existing research on the mannose receptor.
  • Analysis of studies on MR's involvement in immune responses.

Main Results:

  • MR is essential for recognizing and clearing microorganisms.
  • MR links innate immunity (phagocytosis) to adaptive immunity.
  • MR influences both humoral and cellular adaptive immune responses.

Conclusions:

  • The mannose receptor is a key component of host defense.
  • MR plays a significant role in initiating and shaping adaptive immunity.

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