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Updated: Aug 11, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Oxidation of lincomycin by hydrogen peroxide restricts its potential biotransformation with haloperoxidases
S Pospísil1, P Sedmera, P Halada
1Institute of Microbiology, Academy of Sciences of the Czech Republic, 124 20 Prague, Czechia. spospis@biomed.cas.cz
Abstract:
Lincomycin biotransformation was conducted by using Streptomyces venezuelae and Streptomyces phaeochromogenes cell-free extracts. Reaction products were isolated and identified by MS and NMR spectroscopy as lincomycin sulfoxide and lincomycin sulfone. Both compounds arise also by chemical oxidation with hydrogen peroxide; this reaction represents a new efficient way for the preparation of lincomycin sulfoxide and lincomycin sulfone and simultaneously excludes the biotransformation of lincomycin using haloperoxidases.
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