Related Experiment Video
Updated: Oct 2, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
How to search for the role of gene-environment interactions for lipids in humans
1Gaubius Laboratory, TNO-PG, P.O. Box 2215, 2301 CE Leiden, The Netherlands. c.kluft@pg.tno.nl
Abstract:
To target the interventions to the requirements of the individuals we need to identify the genes and the alleles which show variations in response pattern. For example, a lipid-lowering diet is effective for most people, but not so for everyone. The search for genetic polymorphisms that affect the response of LDL cholesterol to diet in humans has been disappointing up till now, and is the first hurdle to take. In addition, it should be realized that the phenotype of serum lipid is not only indicated by the blood level, but is multifaceted. A complication of gene-environment interactions is that in the chain of environmental factor, intermediate phenotype, and pathogenetic process we have the possibility of genetic variability at all levels.
Related Concept Videos
Gene-Environment Interactions
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Pharmacogenomics: Identification of New Drug Targets
Lipid Catabolism
Lipid Digestion
Pharmacogenetics of Drug Metabolism: Overview

