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Advances in high-throughput mass spectrometry.

K L Morand1, T M Burt, B T Regg

  • 1Procter & Gamble Pharmaceuticals, Healthcare Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040-8006, USA. morand.kl@pg.com

Current Opinion in Drug Discovery & Development
|March 20, 2002
PubMed
Summary

High-throughput drug discovery leverages mass spectrometry and HPLC-MS for rapid advancement. New instrumentation enhances capabilities from synthesis to ADME profiling, supported by advanced data management tools.

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Area of Science:

  • Pharmaceutical Sciences
  • Analytical Chemistry
  • Biotechnology

Background:

  • The pharmaceutical industry prioritizes rapid progression of new chemical entities and biological agents.
  • High-throughput drug discovery demands efficient analytical techniques for characterization and profiling.
  • Mass spectrometry (MS) and high-performance liquid chromatography-mass spectrometry (HPLC-MS) are crucial tools in modern drug development.

Purpose of the Study:

  • To highlight the instrumental role of mass spectrometry in advancing high-throughput drug discovery.
  • To discuss the expansion of MS capabilities in drug discovery pipelines.
  • To underscore the importance of data management in handling large-scale analytical data.

Main Methods:

  • Utilizing mass spectrometry and HPLC-MS for various stages of drug discovery.

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  • Employing advanced instrumentation for enhanced analytical throughput and sensitivity.
  • Implementing data management tools for automated data reduction, archival, and mining.

    • Main Results:

    • MS and HPLC-MS have significantly supported and advanced all aspects of high-throughput drug discovery.
    • New instrumentation has broadened MS applications, including synthesis product characterization and ADME profiling.
    • Advances in MS capacity and throughput have driven the development of sophisticated data management solutions.

    Conclusions:

    • Mass spectrometry is indispensable for the rapid progression of drug discovery and development.
    • Technological advancements in MS and data handling are key to meeting the demands of modern pharmaceutical research.
    • Integrated data management and analytical data are essential for efficient drug candidate progression.