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Updated: Jul 26, 2026

Quantitative Analyses of all Influenza Type A Viral Hemagglutinins and Neuraminidases using Universal Antibodies in Simple Slot Blot Assays
Published on: April 4, 2011
Synthesis of influenza neuraminidase inhibitors
A F Abdel-Magid1, C A Maryanoff, S J Mehrman
1RW Johnson Pharmaceutical Research Institute, Drug Evaluation-Chemical Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA. amagid@prius.jnj.com
Abstract:
Influenza neuraminidase inhibitors provide a means to combat flu, a potentially very serious disease. For the first time, there is a way to treat influenza by blocking the influenza enzyme neuraminidase to stop or slow the progression of infection. The diverse structures and synthesis of several influenza neuraminidase inhibitors are discussed. Contributions from chemical process development groups are highlighted for those compounds that have reached the market, such as zanamivir and oseltamivir phosphate.
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